2010 Holy Cross Women's Lacrosse Schedule & Results
| Overall | Pct. | Conf. | Pct. | Streak | Home | Away | Neutral |
| 6-11 | .353 | 3-3 | .500 | Lost 1 | 5-2 | 0-9 | 1-0 |
| Date | Opponent | Notes | Result | Time/Status | Links |
| Feb. 17 | at Massachusetts | L, 15-6 | Final | Boxscore Recap | |
| Feb. 24 | at New Hampshire | L, 10-4 | Final | Boxscore Recap | |
| Feb. 27 | at Yale | L, 8-5 | Final | Boxscore Recap | |
| Mar. 3 | vs. Mount St. Mary's @ Denver, Colo. | W, 12-10 | Final |
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| Mar. 6 | at Denver | L, 12-6 | Final |
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| Mar. 13 | Vermont | W, 12-10 | Final | Boxscore Recap | |
| Mar. 17 | Boston College | L, 13-7 | Final |
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| Mar. 20 | at Colgate * | L, 14-13 | Final |
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| Mar. 24 | Connecticut | L, 11-10 | Final |
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| Mar. 27 | at Navy * | L, 10-4 | Final | Boxscore Recap | |
| Apr. 3 | Bucknell * | W, 15-7 | Final |
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| Apr. 6 | Fairfield | W, 14-12 | Final - OT | Boxscore Recap | |
| Apr. 10 | at Lehigh * | L, 14-7 | Final | Boxscore Recap | |
| Apr. 14 | at Harvard | L, 15-9 | Final | Boxscore Recap | |
| Apr. 17 | Lafayette * | W, 13-4 | Final | Boxscore Recap | |
| Apr. 24 | American * | W, 16-11 | Final |
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| Apr. 30 | at Lehigh | Patriot League Semifinals | L, 9-8 | Final | Boxscore Recap |
| Home events in bold * Conference events # Exhibition events All times listed are Eastern Time | |||||
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