Considered by Coach Dr. Eddie Anderson to be one of the greatest lineman he ever coached, Desmarais began his Crusader career at guard and later converted to a center. While at HC, he earned Catholic College All American and Associated Press All American Honorable Mention recognition. He started at center in the Senior Bowl after his senior year. He was also the first-ever lineman winner of the James Davitt Award. Drafted by the New York Giants and Dallas Cowboys, he instead pursued a career in business.