Murphy captained the 1942 Holy Cross football team that achieved perhaps the program's most famous victory, the 55-12 upset over Boston College, which also snapped HC's three-game losing streak in the series. His efforts during his career were also instrumental in victories over Carnegie Tech in 1940 and Temple in 1942, and he was recognized with an invitation to the East-West Shrine Game in California. He was honored as All-East and All-New England in his senior season. Also a competitor in five events on the track team, Murphy became a teacher and coach at Dracut High School. Two of his sons, Ed '70 and Dave '82, also played football for the Cross.
He was inducted into the Crusader Football Legends Ring of Fame in 2010, as part of its inaugural class. See a Photo Gallery of the event.